Most differentiated or nonproliferating normal cells (7–9) but The level ofĮxpression of HMGA1a/b is low or almost undetectable in Lymphomas and neuroblastic malignancies (4 – 6). pancreas,īreast, prostate, cervi cal, gastric, colorectal cancer as well as Is associated with different types of tumors, e.g. ITC, isothermal titration calorimetry N/P, nitrogen/phosphate PEI, ⫹49-30-726247-225 E-mail: abbreviations used are: HMGA1, high mobility group protein A1 To whom correspondence should be addressed. S1–S4 and Table S1.īoth authors contributed equally to this work. The on-line version of this article (available at ) contains supplemental Figs. All authors are employees of NOXXON Pharma AG, aĬompany that has a commercial interest in Spiegelmers. * This work was supported by the State of Berlin/Investitionsbank Berlin The recognition and alteration of the DNA double helix andĬhromatin substrates has been linked to the development of Their ability to regulate the activity of several genes through To modulation of chromatin and nucleosome remodeling. They act as architectural transcription factors by binding viaĪT hook motifs to the minor groove of AT-rich DNA, leading Group A1 proteins HMGA1a,3 HMGA1b, and HMGA1c belong to one protein family encoded by the HMGA1 gene. The mammalian nonhistone chromatin high mobility Purschke, Dirk Eulberg, Stefan Vonhoff,įrom NOXXON Pharma AG, Max-Dohrn-Strasse 8-10, D-10589 Berlin, Germany Received for publication, August 24, 2010, and in revised form, OctoPublished, JBC Papers in Press, October 20, 2010, DOI 10.1074/jbc.M110.178533Ĭhristian Maasch1, Axel Vater1, Klaus Buchner, Werner G. Polyetheylenimine-Polyplexes of Spiegelmer NOX-A50ĭirected against Intracellular High Mobility Group Protein A1 © 2010 by The American Society for Biochemistry and Molecular Biology, Inc.
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